Research project

The Systems Biology of Reproduction Research Group studies the obstetrical, biological, immunological, pathological and systems biological aspects of the ‘Great Obstetrical Syndromes’. The importance of the topic is supported by the fact that 70% of pregnancies and 15% of clinically recognized pregnancies end with miscarriage, and 25% of pregnant women have obstetrical syndromes that may have a severe impact on the health of both mother and child. The research group studies and characterizes signal transduction pathways that may play a key role in the development of miscarriages and obstetrical syndromes. The focus is on the systems biological investigation of the complex and overlapping dysregulation of maternal-fetal immune tolerance, trophoblast invasion and differentiation. Besides describing molecular pathways and signalling networks of pregnancy complications, our investigations may also reveal novel biomarkers and drug targets.

Scientific collaborations

  • Research Centre for Natural Sciences
  • University of Debrecen
  • Eötvös Loránd University
  • University of Pécs
  • Semmelweis University
  • Petz Aladár County Teaching Hospital (Győr)
  • Biological Research Centre (Szeged)
  • GraviDiagnostics Ltd.
  • Maternity Clinic (Budapest)
  • PentaCore Ltd.
  • Perinatology Research Branch, National Institutes of Health (Detroit, MI, USA)
  • Wayne State University (Detroit, MI, USA)
  • University of Southern California (Los Angeles, CA, USA)
  • Zymo Research Corporation (Irvine, CA, USA)
  • Ben Gurion University (Beer Sheva, Israel)
  • University of Basel (Basel, Switzerland)
  • Medical University of Vienna (Vienna, Austria)
  • Monash University (Clayton, Australia)
  • Universitätsklinikum Hamburg-Eppendorf (Hamburg, Germany)
  • Biognosys AG(Schlieren, Switzerland)
  • University of Bologna (Bologna, Italy)
  • Tampere University (Tampere, Finland)

Teaching activity

Postgradual training:

  • Semmelweis University – Chapters from the immunobiology of pregnancy
  • Eötvös Loránd University – The systems biological view of the immunology of pregnancy

PhD topic:

  • Semmelweis University, Károly Rácz Doctoral School of Clinical Medicine – Pathomechanisms, early prediction and diagnosis of the Great Obstetrical Syndromes
  • Eötvös Loránd University, Doctoral School of Biology – Cellular and molecular level immmune regulation of maternal-fetal attachment

Research news

Current grant support

  • NKFIH 2020-1.1.2-PIACI-KFI-2021-00273
  • NKFIH 2019-2.1.7-ERA-NET-2020-00014

Perinatal Biobank news

Interviews, presentations

Our research group on the cover



Nándor Gábor Than, MD PhD, senior research fellow



Name Status Phone Office
Baunoch Judit laboratory assistant +36 1 3826 674 É2.07
Györffy Dániel research fellow +36 1 3826 717 D3.08B
Horváth Irén external member    
Jelinek Andor biobank coordinator +36 1 3826 641 É2.07
Király Péter external member    
prof. Matko János external member    
Nagy Szilvia external member    
Oravecz Orsolya PhD student +36 1 3826 641 É2.07
Papp-Balogh Andrea research fellow +36 1 3826 641 É2.07
Posta Máté PhD student +36 1 3826 641 É2.07
Szalai Gábor external member    
Szilágyi András senior research fellow +36 1 3826 717 D3.08B
Szödényi Ákos research fellow +36 1 3826 788 D3.11A
Than Nándor Gábor group leader +36 1 3826 788 D3.11A